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BASELINE ASSESSMENT ALONG WITH MEDICAL AND FAMILY HISTORIES CAN UNCOVER HIDDEN MANIFESTATIONS OF HPP.1-4

Patients may not be aware that current and past symptoms could be caused by HPP. 4

SELECT APPROPRIATE TESTS/ASSESSMENTS FROM THE FOLLOWING (NOT ALL ARE REQUIRED):
Possible hidden manifestations
Tests and assessments to consider
Skeletal
Pain and muscle weakness
Renal
Dental
Growth / Development
Physical function and quality of life

A physical or occupational therapist can help evaluate and/or assist with the management of the patient’s physical function and disability. 2,30

Abbreviations: 6MWT, 6-minute walk test; BOT-2, Bruininks-Oseretsky Test of Motor Proficiency; BPI, Brief Pain Inventory; DDST, Denver Developmental Screening Test; DXA, dual-energy X-ray absorptiometry; HHD, handheld dynamometry; NIPS, Neonatal Infant Pain Scale; PedsQL, Paediatric Quality of Life Inventory; SF-36, 36-item Short Form Health Survey.

1. Rockman-Greenberg C. Pediatr Endocrinol Rev. 2013;10(suppl 2):380-388. 2. Mornet E, Nunes ME. GeneReviews. Seattle, WA: University of Washington, Seattle; 1993. http://www.ncbi.nlm.nih.gov/books/NBK1150/. Published November 20, 2007. Updated February 4, 2016. Accessed June 7, 2016. 3. Whyte MP. Genetics of Bone Biology and Skeletal Disease. London, UK: Academic Press; 2013:337-360. 4. Whyte MP, et al. Poster presented at: 39th Annual Congress of the European Calcified Tissue Society (ECTS); May 19-23, 2012; Stockholm, Sweden. 5. Whyte MP. Principles of Bone Biology. Vol 2. 3rd ed. San Diego, CA: Academic Press; 2008:1573-1598. 6. Whyte MP, et al. J Clin Endocrinol Metab. 2007;92(4):1203-1208. 7. Barvencik F, et al. Osteoporos Int. 2011;22(10):2667-2675. 8. Coe JD, et al. J Bone Joint Surg Am. 1986;68(7):981-990. 9. Gagnon C, et al. J Clin Endocrinol Metab. 2010;95(3):1007-1012. 10. Schalin-Jäntti C, et al. J Clin Endocrinol Metab. 2010;95(12):5174-5179. 11. Data on file, Alexion Pharmaceuticals. 12. Seshia SS, et al. Arch Dis Child. 1990;65(1):130-131. 13. Whyte MP, et al. [abstract LB-OR01]. Endocrine Society’s 97th Annual Meeting and Expo website. https://endo.confex.com/endo/2015endo/webprogram/Paper22822.html. Accessed June 7, 2016. 14. Breivik H, et al. Br J Anaesth. 2008;101(1):17-24. 15. Hébert LJ, et al. Pediatr Phys Ther. 2015;27(4):414-423. 16. Fallon MD, et al. Medicine. 1984;63(1):12-24. 17. Mohn A, et al. Acta Paediatr. 2011;100(7):e43-e46. 18. Eade AWT, et al. Ann Rheum Dis. 1981;40(2):164-170. 19. Whyte MP, et al. J Clin Endocrinol Metab. 2013;98(12):4606-4612. 20. Reibel A, et al. Orphanet J Rare Dis. 2009;4:6. http://www.ojrd.com/content/4/1/6. Published February 21, 2009. Accessed June 7, 2016. 21. Whyte MP, et al. Am J Med. 1982;72(4):631-641. 22. Silva I, et al. Acta Rheumatol Port. 2012;37(1):92-96. 23. Foster BL, et al. J Dent Res. 2014;93(suppl 7):7S-19S. 24. Watanabe H, et al. J Periodontol. 1993;64(3):174-180. 25. Beck C, et al. Rheumatol Int. 2011;31(10):1315-1320. 26. Girschick HJ, et al. Bone. 1999;25(5):603-607. 27. Girschick HJ, et al. Orphanet J Rare Dis. 2006;1:24. http://www.ojrd.com/content/1/1/24. Published June 28, 2006. Accessed June 7, 2016. 28. Weber TJ, et al. Poster presented at: Endocrine Society Annual Meeting; March 5-8, 2015; San Diego, CA. 29. Ware JE Jr. Med Care. 1992;30(6):473-483. 30. Phillips D, et al. Poster presented at: Endocrine Society Annual Meeting; March 5-8, 2015; San Diego, CA.



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Copyright © 2016, Alexion Pharmaceuticals, Inc. All rights reserved. GL/UNB-HPP/16/0028

DO YOU
SUSPECT HPP
IN ANY PATIENT?

Contact Alexion for any query

LOOK FOR LOW ALKALINE PHOSPHATASE, HAVE YOU SEEN IT?

LOW ALKALINE PHOSPHATASE ACTIVITY causes HYPOPHOSPHATASIA (HPP), a progressive, debilitating and potentially life-threatening rare disease that affects patients of all ages.1-3

1.Whyte MP. Ann N Y Acad Sci. 2010;1192:190-200. / 2.Mornet E, Nunes ME. GeneReviews. Seattle, WA: University of Washington, Seattle; 1993. https://www.ncbi.nlm.nih.gov/books/N BK1150/. Published November 20, 2007. Updated August 5, 2010. Accessed July 11, 2011 / 3. Rockman-Greenberg C. Pediatr Endocrinol Rev. 2013;10(suppl 2):380-388.

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