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REFERENCE INTERVAL ADOPTION IN 3 STEPS IS POSSIBLE
WITH LARGE AND ROBUST STUDIES, SUCH AS CALIPER.1

Developing pediatric reference intervals locally is challenging, so most laboratories use published data.4 This approach can be reliable with data from large, robust, well-documented studies such as CALIPER.4

1. Colantonio et al.Clin Chem. 2012;58(5):854-868; 2. Estey et al. Clin Biochem. 2013;46(13-14):1197-1219; 3. Horowitz et al. Defining, Establishing, and Verifying Reference Intervals in
the Clinical Laboratory; Approved Guideline—Third Edition. 3rd ed. Clinical and Laboratory Standards Institute; 2010. 4. Friedberg et al. Arch Pathol Lab Med. 2007;131(3):348-357.

DO YOU
SUSPECT HPP
IN ANY PATIENT?

Contact Alexion for any query

LOOK FOR LOW ALKALINE PHOSPHATASE, HAVE YOU SEEN IT?

LOW ALKALINE PHOSPHATASE ACTIVITY causes HYPOPHOSPHATASIA (HPP), a progressive, debilitating and potentially life-threatening rare disease that affects patients of all ages.1-3

1.Whyte MP. Ann N Y Acad Sci. 2010;1192:190-200. / 2.Mornet E, Nunes ME. GeneReviews. Seattle, WA: University of Washington, Seattle; 1993. https://www.ncbi.nlm.nih.gov/books/N BK1150/. Published November 20, 2007. Updated August 5, 2010. Accessed July 11, 2011 / 3. Rockman-Greenberg C. Pediatr Endocrinol Rev. 2013;10(suppl 2):380-388.

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